Let's start with her first big role as the confused mother trying to win back custody of her son in Kramer vs. Kramer. We defy you not to cry at the end.

In Sophie's Choice, Meryl Streep establishes herself as the best actor in many generations in this dark tale of a Holocaust survivor.

The epic romance of Out of Africa shows off all of Meryl Streep's many talents in the very best light.

In one of our all-time favorite comedies, Defending Your Life, Meryl Streep and Albert Brooks fall in love in heaven while they await the verdicts from the trials where it is determined if they go on to paradise or must return to earth to try humanity one more time.

Meryl Streep successfully takes on multiple roles in this HBO mini-series version of the Tony Award winning play, Angels in America.

Meryl Streep is hilarious as the super-demanding Prada wearing Fashion Editor in The Devil Wears Prada.

One you might have missed ... Meryl Streep is a mother coming to grips with the fact that her young son has committed murder in Before and After.

Meryl Streep and Shirley MacClaine are mother and daughter in this movie adaptation of Carrie Fisher's book in Postcards from the Edge.

Meryl Streep, Bruce Willis and Goldie Hawn will make you laugh in the satire on the search for beauty in Death Becomes Her.

Meryl Streep and Clint Eastwood elevate a sappy romantic novel to an intelligent movie love story in The Bridges of Madison County.