Citizen Kane (although a box office failure when first released)
Orson Welles career took a very unusual trajectory. What was considered failure was later hailed as masterpiece. However, some of his acting choices (The Muppet Movie, Hot Money) certainly could be labeled career lows.
Battles with his weight
Battle between Welles and William Randolf Hearst over Citizen Kane
Battles against the studio system
Commercial, voice over actor
"You got hellfire and damnation in you, Jody Varner, but you got redemption too. When I think of the hate that put me in there and locked the door and set fire to it, and when I think of the love that wouldn't let me go... I got me a son again. I got me a good right arm - and a left."
Orson Welles had a cameo is which Mel Brooks classic comedy?